New algorithm for rheological studies in chronic heart failure
E. Arziani
, M. Gotsadze
, T. Kandashvili
, N. Momtselidze
, G. Kuchava
, M. Mantskava
, N. Antonova
Abstract: Objective: Chronic heart failure is a very serious disease with widespread disability and a high rate of disability and mortality. The aim of the study is a comprehensive assessment of the rheological properties of blood in coronary heart disease against the background of a systematic assessment of red blood cell aggregation. Materials and methods: Blood rheological properties in a group of patients with chronic heart failure and a control group were studied. For this, we composed the new algorithm of research, which consists of a comprehensive assessment of red blood cell aggregation by using a systematic approach (we investigated erythrocyte aggregation index, erythrocyte aggregation quality, mean of erythrocyte count in aggregate), as well as the deformability of erythrocyte membrane and hematocrit. Results: In the group of patients with chronic heart failure compared to the control group, there was a significantly higher blood viscosity at all shear stresses, with a significant increase in erythrocyte aggregability. The changes in deformation were 8-10% and 9-10%, respectively. Discussion: Against the background of increasing plasma viscosity, erythrocyte aggregation increases in each vector due to the area of aggregated erythrocytes, due to the number of aggregates and due to the number of erythrocytes in each aggregate. Such a complex approach allows a reliable assessment of the aggregation phenomenon itself in detail. Conclusion: The new algorithm represents a comprehensive assessment of blood rheology. It allows for a detailed assessment of blood flow, which is very important for further improvement of the tactics of diagnosing the disease in the early stages and successful treatment in patients with chronic heart failure.
Series on Biomechanics, Vol.39, No.1(2025), 59-66
DOI: 10.7546/SB.07.03.2025
Keywords: aggregation; deformation; RBC; viscosity
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| Date published: 2025-10-28
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