Rheological characteristics of blood that determine its fluidity and transport potential: ways to correct disorders
A.V. Muravyov
, I.A. Tikhomirova
, P.V. Mikhailov
, A.V. Zamyshlyaev
Abstract: Objective: Whole blood viscosity (WBV) is affected by plasma viscosity (PV), hematocrit, red blood cell aggregation (RBCA), their deformability (RBCD) and shear stress. Materials and methods: Two groups of volunteers participated in the study: group 1 (n=28) – healthy individuals. Group 2 (n=30) – hypertensive patients. The above rheological parameters were recorded in individuals. Results: When comparing the two groups, an increase in WBV by 30% was found in individuals of group 2. Correlation analysis showed that all basic rheological characteristics significantly correlated with WBV. This made it possible to obtain linear regression equations, where each of the rheological factors was related to WBV. Based on these equations, a computational model was implemented and the calculated WBV was determined with a positive change of each of the five factors by 10%. It was found that the equation linking WBV with RBCD gave the largest decrease in WBV (by 32%).
Conclusion: The predicted change in WBV under the influence of other characteristics was smaller (from 6 to 12%). It can be assumed that the RBCD is an important link in the control of blood fluidity and its transport capabilities.
Series on Biomechanics, Vol.39, No.2 (2025), 54-62
DOI: 10.7546/SB.06.02.2025
Keywords: Blood viscosity; computational model; hematocrit (Нсt); plasma viscosity; red blood cell deformability
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| Date published: 2025-07-09
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