A new method for assessing the effectiveness of experimental diabetic models for assessing blood rheology

N.Sakhanberidze, M.Namoradze, N.Charkviani, N.Momtselidze, G.Kuchava, N.Antonova, M.Mantskava

Abstract: Objective. Diabetes is a complex system of diseases associated with violating all types of metabolism: carbohydrate, fat, protein, mineral and water-salt. Diabetes requires special attention from the fundamental scientific and clinical medicine sides. Of course, rheology is one of the factors that change in diabetes and rheological studies in diabetes are of relevance for the success and timely treatment of manifestations and complications of diabetes. Materials and Methods. Experimental models of diabetes are widely used in modern biomechanics to determine several factors in the course and treatment of the disease. To investigate effectiveness of different experimental models, we introduced the parameter effective coefficient of models for rheological research and conducted laboratory rheological studies on various types of models (surgical, dithizone, alloxan, streptozotocin). Results. Considering all the factors, it turned out that the streptozotocin model is most suitable for rheological studies. Discussion. Existing useful models of diabetes have not yet been assessed in terms of the suitability of rheological studies. Some models of diabetes may have established themselves as easily and comfortably used, but for rheological research they are not effective. The coefficient we have introduced describes the effectiveness of the model for studying the rheology in diabetes. Conclusion. Considering all the factors, we have concluded that the streptozotocin model is the most suitable for rheological studies.

Series on Biomechanics, Vol.39, No.1 (2025),17-23
DOI:10.7546/SB.01.03.2025

Keywords: aggregation; deformation; RBC; Rheological properties

DOI: 10.7546/SB.01.03.2025

Date published: 2025-03-25