Simultaneous study of coagulation and rheological systems in patients with ischemic stroke
N. Kharaishvili
, M. Mantskava
, N. Momtselidze
, G. Kuchava
, Sh. Ingorokva
, N. Antonova
Abstract: Objective: Stroke is one of the most serious health and social problems worldwide. Mortality from the disease ranks second and is 8% among men and 16% among women. The hemostatic system of elderly patients in the acute period has features that have not been sufficiently studied. Understanding the mechanisms of interaction between coagulation and rheological systems makes it possible to influence processes, improving the outcome of the disease. The purpose of this study is to conduct a comparative analysis of the state of the anticoagulant systems and the blood rheology system in elderly patients in the acute period and in the control group. Materials and methods: The state of the hemostatic system was studied in 36 men and women (65-75 years old) with stroke. We investigated the state of rheological and coagulation systems in patients with acute ischemic stroke (n=21) and in control group (n=15). The patient’s age ranged from 65 to 75 years old. We studied antithrombin III fibrinogen as coagulation system properties and erythrocyte aggregation, deformation and in theoretical rheological parameter as the main markers of blood rheology. Results: We obtained statistically significant differences in the level of antithrombin III activity and fibrinogen in patients who suffered an ischemic stroke at the time of admission to comparative of control group. The deformation of the erythrocytes changed due to the strengthening of the hard membranes compared to the control, but it did not correlate with the clinical condition of the patients. The change in the rheology of the blood was displayed in calculations by RI in silico. Conclusion: Simultaneous study of coagulation and rheological systems in patients with stroke is very important for effective treatment, personification of patients, and can also become a prognostic marker of stroke.
Series on Biomechanics, Vol.38, No.4(2024),48-52
DOI: 10.7546/SB.07.04.2024
Keywords: acute ischemic stroke; aggregation; deformation; Erythrocyte; in silico
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| Date published: 2024-12-11
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