Hemorheological disorders in patients with peripheral occlusive arterial disease and ways to correct them
A. Zamyshliaev
, I. Tikhomirova
, A. Muravyov
, N. Antonova
, I. Velcheva
Abstract: In vascular pathology, the reserve of vascular dilatation decreases, and the rheological properties of blood can either compensate for this negative modification or worsen tissue perfusion in a given vascular region. In view of the above, the purpose of this study was to investigate the hemorheological profile in patients with peripheral occlusive arterial disease (POAD). In 26 patients with POAD blood viscosity (BV1 and BV2) at high and low shear stresses, plasma viscosity (PV) and red blood cell (RBC) suspension viscosity (SV), hematocrit (Hct), red blood cell deformability (RBCD) and their aggregation (RBCA) were recorded and compared with the blood rheology of healthy individuals. In in vitro experiments, RBC microrheological responses to biologically active compounds –signaling molecules that have a positive effect on RBC microrheology, were analyzed. It was found that most of the hemorheological characteristics were abnormally changed in patients compared with healthy individuals. To a somewhat greater extent, this concerned the RBC microrheological parameters. The RBC incubation with pentoxifylline and vinpocetine revealed a positive microrheological effect. To analyze possible molecular cellular targets for the above compounds, experiments were performed with the incubation of erythrocytes with stimulators of adenylate cyclase (Forskolin), guanylate cyclase (nitric oxide), dB-cAMP (dibutyryl – cAMP), and sodium nitroprusside (SNP). Statistically significant positive RBC microrheological responses to these compounds were obtained. Taken together, it can be concluded that in POAD, along with vascular pathology, there is a negative change in the hemorheological profile. However, the data obtained in in vitro experiments indicate the possibility of correcting the existing changes in the RBC microrheology of patients.
Series on Biomechanics, Vol.37, No.3 (2023), 3-10
Keywords: hemorheological profile; microrheology; phosphodiesterase (PDE) inhibitors; POAD; red blood cells; signaling molecules
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| Date published: 2023-08-02
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