Multiparameter analysis of mechanokinetics of the contractile response of smooth muscles

S. Kosterin, O. Tsymbalyuk, O. Holden

Abstract: This article proposes the empirical multiparameter method of complex mechanokinetic analysis of the spontaneous contractile response of visceral smooth muscles under isometric mode. The graphical linearization criterion for the description of the total mechanokinetic curve of the contraction-relaxation cycle was presented. The quantitative regularities, subject to three universal principles, were determined. The proposed method allows determining a number of quantitative indices for thorough description of the mechanokinetic curve. Possible applications of the proposed method in the studies of the effects of physicochemical (hypermagnesium solution), metabolic (uterotonic hormone oxytocin) and pharmacological (using the example of calix [4]arene C-90) factors on electro- and pharmacomechanical coupling were described. The authors believe that this study will benefit researchers in the field of biophysics, biophysical chemistry, physiology, pharmacology of smooth muscles, and biotechnology.

Series on Biomechanics, Vol.35 No.1 (2021),14-30

Keywords: electro- and pharmacomechanical coupling; mechanokinetical parameters; Smooth muscles

Date published: 2021-04-04