Preliminary data for analytical and experimental studies of the rheological properties in the frame of international multidisciplinary project Georgian reality: the sustainability of scientific research during the COVID-19 pandemic

M. Mantskava, L. Akhvlediani, N. Antonova, A. Bilanishvili, T. Bostiashvili, J.- F. Brun, G. Chkadua, P. Faber, N. Jojua, T. Kalichava, R. Kiriakidi, T. Kotaria, G. Kuchava, N. Maisuraze, M. Makharadze, N. Mitskevihi, I. Mirianashvili, N. Momtselidze, N. Nizharadze, Sh. Potskhishvili, A. Rabiei, C. Saldanha, A. Silva-Herdade, T. Sanikidze, L. Sturua, S. Uchaneishvili, T. Urdulashvili, A. Zardoshtian

Abstract: The description of the analytical clinical and experimental data has been presented for patients with COVID-19 from different countries. The article presents detailed description of the rheological situation in patients with neuropathic and cardiological problems, as well as the “COVID toes”, during development of COVID-19 infection. The data was compared with results of rheological studies in analogical groups of patients without COVID-19. The disease “COVID toes” was compared with Raynaud’ phenomenon). The article describes the effects of various anticoagulants on blood rheology and prevention coagulopathies after describing Protocols. In vivo and in vitro experiments evaluating a range of rheological parameters under different anticoagulants’ influence, were analyzed, RBC aggregation, RBC deformability and plasma viscosity were examined with innovative measurement technologies and quantitative methods. The work presents a new scientific focus and research area, able to “transport” the newest experimental and analytical conclusions to the clinical practice – for successful management and treatment of COVID-19 Pandemic.

Series on Biomechanics, Vol.34, No.3 (2020), 67 - 81

Keywords: COVID toes; COVID-19; Ischemic brain infarct; Myocardial infarction; Raynauds phenomenon; RBC aggregability; RBC deformability

Date published: 2020-10-15