Numerical modeling of indomethacin release from polymersome nanoparticles based on PNIPAM-G-PEO graft copolymer

R. Blagoeva, A. Nedev

Abstract: Numerical modeling of the release of the socially important drug indomethacin from various polymersome nanoparticles (NPs) is presented. The numerical approach to prediction of drug liberation from the considered NPs, offered by the authors, is used in the case of predominant dissolution mechanism. The model is validated for three temperatures and three values of ethanol concentration in the release medium on the basis of available experimental data. The reliability of the proposed numerical approach is analyzed. The best goodness of fit is obtained in the case of vesicular NPs for 10% and 20% ethanol at 370C; 10% ethanol at 420C and in the case of micellar NPs for 5% and 10% ethanol at 370C. In order to evaluate the fractional drug release into the period of 24 hours numerical simulations are performed. The presented numerical approach can be used as an effective tool in the design of new nanocarriers of the considered type.

Series on Biomechanics, Vol.31, No.2 (2017), 45-49

Keywords: Dissolution; numerical modeling; polymersome nanoparticles

Date published: 2017-10-27