Some results of assessing the state of microcirculation and Type D personality traits of individuals with T1DM
N. Antonova
, P. Miteva
Abstract: Background: Monitoring physiological and biophysical parameters using wearable diagnostic devices has become increasingly relevant over the past decade. Early identification of functional and metabolic alterations at the microcirculatory level is crucial in type 1 diabetes mellitus (T1DM).
Objectives: This pilot study aims to evaluate the capabilities of dual-channel portable MFED-2 analyzers for assessing microcirculation and tissue oxygenation and to correlate the results with the Denollet Type D personality scale and the dietary habits, physical activity and work characteristics of the patients.
Materials and methods: A comparative assessment of microcirculation and oxidative metabolism in one healthy subject and three T1DM individuals was performed sequentially on the foot and wrist using MFED-2, which combines two diagnostic technologies: laser Doppler flowmetry (LDF) and fluorescence spectroscopy. The Denollet D-14 scale was used to measure social inhibition and negative affect as predictors of poor glycemic control and diabetic complications. Semi-structured interviews were used to understand the patients' history, dietary and fitness habits, and adherence to therapy.
Results: Comparative microcirculatory and metabolic profiles (case reports) showed a decrease in mean microcirculatory perfusion (M), endothelial regulatory activity (Ae) and the index of oxidative metabolism (POM) and an increase in the coefficient of variation (Kv) in T1DM group. None of the tested T1DM patients was classified as having a type D personality, and two of them had threshold values on two subscales (social inhibition and negative affect).
Conclusion: The use of portable laser analyzers on symmetrical areas of the body revealed decreased perfusion and oxidative metabolism index in the T1DM patients and increased coefficient of variation. Although the clinical richness and consistent tendencies between the tested socio-psychological variables and the obtained results were not observed, this calls for a larger sample and a broader model of investigation.
Series on Biomechanics, Vol.39, No. 4 (2025), 76-90
DOI: 10.7546/SB.09.04.2025
Keywords: diabetes mellitus type 1 (T1DM); fluorescence spectroscopy; laser Doppler flowmetry (LDF); microcirculation; oxidative metabolism; personality traits; regulatory mechanisms; wavelet analysis
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| Date published: 2025-12-12
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