Some results of assessing the state of microcirculation and Type D personality traits of individuals with T1DM
N. Antonova
, P. Miteva
, P. MitevaAbstract: Background: Monitoring physiological and biophysical parameters by means of wearable diagnostic devices has become more and more relevant over the past decade. Early identification of functional and metabolic alterations at the microcirculatory level is particularly important in type 1 diabetes mellitus (T1DM).
Objectives: This pilot study aims to evaluate the diagnostic capabilities of dual-channel portable MFED-2 analyzers for assessing microcirculation and tissue oxygenation and to correlate the results with the Denollet Type D personality scale and the dietary habits, physical activity and work characteristics of the patients.
Materials and methods: A comparative assessment of microcirculation and oxidative metabolism in one healthy subject and in three individuals with T1DM was performed using the MFED-2 multimodal analyzer, which combines two diagnostic technologies: laser Doppler flowmetry and fluorescence spectroscopy. Measurements were performed sequentially at two anatomical sites: the foot and wrist. The well-known Denollet D-14 type scale was used to measure social inhibition and negative affect as predictors of poor glycemic control and diabetic complications. Semi-structured interviews were used to understand the patients' history, dietary and fitness habits, and adherence to therapy.
Results: The main parameters obtained by peripheral blood flow measurements using a non-invasive portable LDF device, as well as some results (case reports), are presented. Comparative microcirculatory and metabolic profiles in the control subject and in T1DM patients show a decrease in the mean microcirculatory perfusion (M), endothelial regulatory activity (Ae) and oxidative metabolism index (POM) and an increase in the coefficient of variation (Kv) in the T1DM group. None of the tested T1DM patients ranked as having Type D personality, two of them defined threshold values on two subscales (Social Inhibition and Negative Affect).
Conclusion: The use of portable laser analyzers on symmetrical areas of the body revealed decreased perfusion and oxidative metabolism index in the T1DM patients and increased coefficient of variation. Clear tendencies between the tested socio-psychological variables and the obtained results were not observed, which calls for a larger sample and a broader model of investigation.
Series on Biomechanics, Vol.39, No. 4 (2025), 76-88
DOI: 10.7546/SB.09.04.2025
Objectives: This pilot study aims to evaluate the diagnostic capabilities of dual-channel portable MFED-2 analyzers for assessing microcirculation and tissue oxygenation and to correlate the results with the Denollet Type D personality scale and the dietary habits, physical activity and work characteristics of the patients.
Materials and methods: A comparative assessment of microcirculation and oxidative metabolism in one healthy subject and in three individuals with T1DM was performed using the MFED-2 multimodal analyzer, which combines two diagnostic technologies: laser Doppler flowmetry and fluorescence spectroscopy. Measurements were performed sequentially at two anatomical sites: the foot and wrist. The well-known Denollet D-14 type scale was used to measure social inhibition and negative affect as predictors of poor glycemic control and diabetic complications. Semi-structured interviews were used to understand the patients' history, dietary and fitness habits, and adherence to therapy.
Results: The main parameters obtained by peripheral blood flow measurements using a non-invasive portable LDF device, as well as some results (case reports), are presented. Comparative microcirculatory and metabolic profiles in the control subject and in T1DM patients show a decrease in the mean microcirculatory perfusion (M), endothelial regulatory activity (Ae) and oxidative metabolism index (POM) and an increase in the coefficient of variation (Kv) in the T1DM group. None of the tested T1DM patients ranked as having Type D personality, two of them defined threshold values on two subscales (Social Inhibition and Negative Affect).
Conclusion: The use of portable laser analyzers on symmetrical areas of the body revealed decreased perfusion and oxidative metabolism index in the T1DM patients and increased coefficient of variation. Clear tendencies between the tested socio-psychological variables and the obtained results were not observed, which calls for a larger sample and a broader model of investigation.
Series on Biomechanics, Vol.39, No. 4 (2025), 76-88
DOI: 10.7546/SB.09.04.2025
Keywords: diabetes mellitus type 1 (T1DM); fluorescence spectroscopy; laser Doppler flowmetry (LDF); microcirculation; oxidative metabolism; personality traits; regulatory mechanisms; wavelet analysis
Date published: 2025-12-12
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