The paradox of low-dose Radonized mineral water: unexpected effects on potassium levels
M. Nikolaishvili, A. Tarkhnishvili, K. Phevadze, D. Natadze, K. Dondoladze
Abstract: Objective: In the present study, we investigated the effects of 96 and 120-hour inhalation of radonized mineral water vapor with a low radon concentration (37 Bq/m³) on the electrolyte balance. Materials and methods: The experiment was conducted using water vapor from a natural radonized spring of Tskaltubo and included the determination of changes in blood electrolytes (calcium, potassium, sodium). Results: After 120 hours of inhalation of radonized mineral water vapor, calcium levels in aggressive rats increased by 0.36 mmol/L, sodium decreased by 5.90 mmol/L, and potassium increased sharply by 7.06 mmol/L; the changes were statistically significant after both 96 and 120 hours of exposure (P < 0.001). Discussion: The changes caused by continuous inhalation of 37 Bq/m³ radonized mineral water vapor for 96 and 120 hours demonstrate that both the duration of inhalation and its intensity play an important role in the body's electrolyte homeostasis. A significant increase in the concentration of potassium in the blood indicates that the body is responding to the intensive and continuous exposure to radon and mineral water components. Conclusion: The study highlights the potential therapeutic value of low-dose radon balneotherapy and requires further studies at the molecular level.
Series on Biomechanics, Vol.39, No.1(2025), 78-82
DOI: 10.7546/SB.09.03.2025
Keywords: behaviour; electrolytes balance; grooming; radiation; radon
| References: (click to open/close) | [1] Nikolaishvili, M., Museliani, T., Jikia, G., Tarkhnishvili, A., & Dondoladze, K., 2024. Late changes in oxidative stress biomarkers after inhalation of low dose radon in young and adult wild rats. Bulletin of the Georgian National Academy of Sciences, 18, 1, 124–129. [2] European Commission., 2013. Council Directive 2013/59/Euratom of 5 December 2013 laying down basic safety standards for protection against the dangers arising from exposure to ionising radiation, and repealing Directives 89/618/Euratom, 90/641/Euratom, 96/29/Euratom, 97/43/Euratom and 2003/122/Euratom. Official Journal of the European Union, L13, 1–73. [3] Dondoladze, K., Nikolaishvili, M., & Zurabashvili, D., 2021. The effect of balneotherapy on the oxidative system and changes in anxiety behavior, enhanced by low doses of radon. International Journal of Radiation Biology, 97, 10, 1461–1469. [4] Nikolaishvili, M. M., Andronikashvili, G. T., Gurashvili, T., Tarkhnishvili, A. A., & Dondoladze, K., 2024. Comparative analysis of memory and behavioral changes after radon-contained mineral water inhalation therapy in aged rats. Georgian Medical News, 345, 45–50. [5] Zhang, Y., Lu, L., Chen, C., Field, R. W., D'Alton, M., & Kahe, K., 2022. Does protracted radon exposure play a role in the development of dementia? Environmental Research, 210, 112980. [6] Dondoladze, K., Nikolaishvili, M., Museliani, T., & Jikia, G., 2022. Effect of radiation on aging processes and telomere length. Problemy Radiatsiinoi Medytsyny ta Radiobiolohii, 27, 107–119. [7] Molla, S., Kumar, R., Singhal, P., & Singh, S., 2024. Physicochemical and spatial distribution patterns of radon and its parent radionuclides in the uranium-mineralized Singhbhum Region, India. Journal of Radioanalytical and Nuclear Chemistry, 334,1, 1021–1032. [8] Markowitz, J. E., 2023. A groom with a view. eLife, 12, e88595. [9] Sinnathamby, E. S., Banh, K. T., Barham, W. T., et al., 2024. Hyperkalemia: Pharmacotherapies and clinical considerations. Cureus, 16, 1, e52994. [10] Nikolaishvili, M., Nanobashvili, Z., Mitagvaria, N., Chkadua, G., Museliani, T., Dondoladze, K., & Jikia, G., 2022. Assessment of integrated antioxidant systems and hormesis effect of radon in experimental studies. Journal of Biosciences and Medicines, 10, 3.
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| Date published: 2025-10-28
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