The relationship between the non-Newtonian properties of blood, its fluidity and transport potential in patients with arterial hypertension

E. Volkova; A. Zamyshliaev; P. Mikhailov; I. Tikhomirova; I. Osetrov; A. Muravyov; N. Antonova

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E. Volkova

, A. Zamyshliaev

, P. Mikhailov

, I. Tikhomirova

, I. Osetrov

, A. Muravyov

, N. Antonova

Abstract: In different parts of the circulation, blood exhibits the properties of a Newtonian and non-Newtonian fluid. Changing the shear conditions and the vascular bed geometry can contribute to a greater manifestation of the non-Newtonian behavior of blood. The latter is combined with a decrease in blood fluidity and its transport potential. The aim of the study was to estimate the effect of changes in non-Newtonian characteristics of blood on its fluidity and transport potential in patients with arterial hypertension (AH).
In two groups (group 1 of healthy subjects, n=22 and group 2 of 20 patients with AH) hemorheological profile parameters were recorded, including blood viscosity (BV) at five increasing shear stresses (SS). At the same SS, the red blood cell (RBC) elongation index (EI) and their ghosts were determined. The data obtained indicate that the flow of blood as a viscous liquid can have a non-Newtonian character both under normal conditions and especially in pathology, for example, in arterial hypertension. The non-Newtonian behavior of blood is very well described by the power-law fluid model. It can be obtained by registering blood viscosity at several, at least five, shear stresses. It was found that the most significant characteristic of the change in the degree of non-Newtonian behavior of blood is the index of consistency, “k” from this equation: y= kx-n. It strongly correlated with blood fluidity and its transport potential mostly in AH patients. In addition, it was found that an increase in the RBC deformation, which is close to a linear type, with a gradual increase in shear stress in the microchamber, is better predicted by the power-law pseudoplastic fluid model.

Series on Biomechanics, Vol.37, No.3 (2023), 11-18

Keywords: arterial hypertension; Blood viscosity; non-Newtonian properties; red blood cell deformability

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DOI: 10.7546/SB.02.03.2023

Date published: 2023-08-02

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