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Series on BIOMECHANICS   ISSN 1313-2458
Array ( [session_started] => 1680029761 [LANGUAGE] => EN [LEPTON_SESSION] => 1 )


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Mathematical modelling and analysis of miRNA regulation coupled with stochastic time delays
S.G. Nikolov, M.I. Nenov
Abstract: MicroRNAs are a class genome-encoded ~22 nucleotide (nt)- long RNAs that silence gene expression by repressing translation and/or by promoting mRNA. In this paper, we investigate the time delay model of a feedback system regulated with miRNA. In our previous paper [10], using the Hopf bifurcation theorem, we predict the occurrence of a limit cycle bifurcation for the time delay parameters. Here, from the accomplished results it becomes clear that miRNA inhibition coupled with a stochastic time delay can have a stabilizing dynamical role.
Keywords: bifurcation point; miRNA; stochastic time delay
Date published: 2013-03-09
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