Numerical modelling of indomethacin release from polymersome nanoparticles solution in the presence of ethanol

R. Blagoeva, A. Nedev, V. Michailova

Abstract: A study of indomethacin release from polymersome nanoparticles solution is presented. In vitro release has been conducted in distilled water containing different ethanol content, as well as different rate of ethanol injection, using the dialysis tube method. In the present work a recently proposed by the author's mathematical model for drug release is validated under the obtained experimental results. It is used for establishing the effect of ethanol content and rate of ethanol injection in the nanoparticles solution upon drug release. Numerical simulation of indomethacin release is performed within a period of 2 days.

Keywords: indomethacin release; numerical modeling; polymersomes

Date published: 2015-06-09